Things to Consider Before Buying CBD E-Liquid

There are many different ways of taking cannabidiol. There are capsules, tinctures, etc. With e-cigarettes becoming very popular lately amongst cigarette smokers, the use of vaporizers has also branched out into our world of natural health. They are now counted as one of the convenient and beneficial ways of taking CBD.

That being said, there are few factors you should look out for before buying buying CBD product in any form.

Dosage

There seems to be a lot of infographics online that give dosage information, but what you need to remember is that everyone is different and metabolisms vary. Like with all news things, be reasonable and start small, working up the dosage based on how you feel until you find the desired effect.

Quality

Like all new things relating to the vape world its open to abuse and unfortunately there are a lot of of CBD producers who are using synthetic CBD so be very careful when buying cleverly marketed CBD vape liquids as the quality and product could actually be harmful to you as unknown compounds etc are introduced to your body. So only buy from certified vendors or make your own to be sure of the quality.

Price

Cheap cannabidiol, (CBD) oils are cheap for a reason. If you searched for ‘CBD oil’ in your search engine right now it would bring up hundreds of different CBD products – and all of them claiming to be the best ever and extracted from the strongest hemp! The interesting thing about them is that most of these producers and distributors offer no tangible evidence to support the claim that their products are the best. Surely, lower prices are more attractive, but think twice before picking the cheap CBD oil over the higher quality one. If you want to make sure you’re getting a safe and effective product, look for quality, not for a low price.

Most importantly, do your research before buying any CBD products. Look out for lab test results that are visible for anyone who wants to see them. Beware of products that claim to cure everything – although cannabidiol has shown promising results in numerous studies, that doesn’t mean to say that it will cure your condition over night!

Cannabidiol vs. epilepsy: Can CBD reduce seizures?

Scientists recently converged in Philadelphia for the American Epilepsy Society’s 69th Annual Meeting, touting new studies and insights in the field of epilepsy. Researchers discussed new findings, including personalized medicine, and the promise of cannabidiol (CBD) in human and animal studies.

A year-long study conducted by epilepsy specialists at the New York University Langone Medical Center have suggested that cannabidiol, a non-psychoactive compound found in cannabis effectively reduces seizure frequency and is safe for most children and young adults who have epilepsy. Research led by Dr. Orinn Devinsky from the Comprehensive Epilepsy Center at Langone followed patients with the condition at 11 epilepsy centres across the US.

In total, 261 study participants between the ages of 1-30 years were given the oral CBD treatment Epidiolex over the course of 12 weeks. Both, researchers and families knew they were receiving CBD treatment. 

Participants were given an oral CBD regimen from 2-5 mg/kg per day and increased dosage until either intolerance occurred or to a maximum dose of either 25 mg/kg or 50 mg/kg per day. Additionally, parents recorded seizures in diaries, which the study team reviewed at each visit. The team also conducted lab screenings at baseline and after 4, 8 and 12 weeks of CBD treatment.

The number of convulsive seizures, called grand mal or tonic-clonic seizures, went down by about half on average. Devinsky says that some children continued to experience benefits on cannabidiol after the trial ended. “In the subsequent periods, which are very encouraging, 9 percent of all patients and 13 percent of those with Dravet Syndrome epilepsy were seizure-free. Many have never been seizure-free before,” he says. 

Evidence suggesting that CBD is effective against treatment-resistant epilepsy may be growing but scientists still know very little about how it works—other than the likelihood that it is “completely different than any other seizure drug we know,” as Devinsky puts it. That’s a good thing, he notes: “One fear is that because of the way that the drugs are tested and screened, we’ve ended up with a lot of ‘me-too’ drugs that are all very similar.”.

Despite of preliminary positive results of the study published last December, researchers (including those who were involved in the study) agree that a full clinical placebo-controlled trial needs to be done. However, that takes time and puts parents in a difficult position, and as Devinsky says “Parents are desperate and they feel the medical community has failed them, which is true in many cases.”. In the meantime most clinicians and researchers advise “cautious optimism” when considering CBD as an epilepsy treatment.

You can read the full study here

How Does CBD Affect Endocannabinoid System?

In our previous blog post we described the Endocannabinoid system and how it works – it’s a compound physiologic network within our bodies, involving cannabinoid receptors. The endogenous cannabinoids and their respective enzymes are in control of maintaining balance in system by regulating the synthesis and breakdown of the active endocannabinoid compounds.

At first, the scientists thought it only responds to endogenous cannabinoids produced by the human body. However, the latest research has found that the system will also recognize and respond to cannabinoids from external sources, including CBD, which is found in hemp.

There are two main types of receptors in the endocannabinoid system. These are CB1 and CB2 receptors. Unlike THC – the main psychoactive compound of cannabis – CBD is unable to bind to either receptor perfectly. This causes stimulation in the cells where the receptors are activated, without being fully latched onto. As CBD is transported through the bloodstream, and endocannabinoid receptors can be found throughout the entire body – including the brain – interactions can take place throughout the entire body, causing widespread and varied effects. It is largely why CBD oil has become such a popular dietary supplement.

Although the endocannabinoid system is the main point of CBD interaction, it is not the only one. So we thought it worth quickly mentioning the other ways CBD interacts with the body. This additional interaction is caused by CBD stimulating other receptors. For example, CBD is thought to activate serotonin receptors. It also stimulates G-protein receptors that affect temperature control and pain perception.

What we know for sure is that CBD is a complex cannabinoid, and the way it interacts with the body is nothing but amazing. The fact we have an internal system that appears to be specifically set up to work with CBD is astonishing. The research already conducted into CBD has found nothing but positive results – so who know what the future of CBD based research could bring.